Hair loss abstract
SOD for treating hair loss is disclosed. The SOD has utility in
a topical pharmaceutical formulation for the cosmetic treatment
of hair loss and the cosmetic stimulation of hair growth. The SOD
comprises copper salicylate, copper aspirinate, indomethacin-copper,
or a complex of an amino acid or peptide and a transition metal.
Hair loss claims
I claim:
1. A method for stimulating hair growth comprising the step of:
applying in a topical pharmaceutical carrier to skin a transition
metal compound having SOD activity, said compound selected from
copper salicylate, copper aspirinate, indomethacin-copper and a
complex of an amino acid or peptide and a transition metal, wherein
the peptide consists of amino acids selected from glycine, histidine,
lysine, arginine, cysteine or methionine.
2. The method of claim 1, wherein the amino acid of the amino acid-metal
complex is selected from glycine, histidine, lysine, arginine, cysteine
and methionine, and the metal is selected from copper, iron, zinc
and manganese.
3. The method of claim 1, wherein the peptide is selected from
histidyl lysine, glycyl histidine, glycyl hystidyl lysine and lysyl
histidyl lysine.
4. The method of claim 1, wherein the transition metal compound
is copper salicylate.
5. The method of claim 1, wherein the transition metal compound
is copper aspirinate.
6. The method of claim 1, wherein the transition metal compound
is indomethacin-copper.
7. a composition suitable for treating hair loss, comprising:
a transition metal compound having SOD activity selected from copper
salicylate, copper aspirinate, indomethacin-copper, and a complex
of a basic amino acid and a transition metal; and
a topical pharmaceutical carrier selected from oil and water emulsions,
urea, propanol, butanol and glycols.
8. The composition of claim 7, wherein the amino acid is selected
from glycine, histidine, lysine, arginine, cysteine and methionine,
and the metal is selected from copper, iron, zinc and manganese.
9. The composition of claim 7, wherein the transition metal compound
is copper salicylate.
10. The composition of claim 7, wherein the transition metal compound
is copper aspirinate.
11. The composition of claim 7, wherein the transition metal compound
is indomethacin-copper.
12. A composition useful for treating hair loss, comprising:
a transition metal compound of the formula R-M having superoxide
dismutase activity wherein R is salicyl, acetylsalicyl or indomethacin,
and M is copper, iron, zinc, or manganese; and
a topical pharmaceutical carrier selected from creams, lotions,
shampoos and cream rinses.
13. The composition of claim 12, wherein R is salicyl.
14. The composition of claim 12, wherein R is acetylsalicyl.
15. The composition of claim 12, wherein R is indomethacin.
16. The composition of claim 12, wherein M is copper.
17. The composition of claim 12, wherein M is iron.
18. The composition of claim 12, wherein M is zinc.
19. The composition of claim 12, wherein M is manganese.
Hair loss description
FIELD OF THE INVENTION
This invention relates to topical superoxide dismutase (SOD), and
the treatment of hair loss herewith.
BACKGROUND OF THE INVENTION
Recently, several anti-alopecia agents such as minoxidil and cyoctol
have gained attention. However, most of these anti-alopecia agents
are only minimally effective in some cases and/or can cause adverse
dermatological or systemic reactions. Minoxidil, for example, is
a therapeutic antihypertensive. Thus, the search continues for new,
safer and more effective anti-alopecia agents which can be used
without the risk of undesirable antihypertensive effects.
SUMMARY OF THE INVENTION
Applicant has discovered that SOD can be used as a topical anti-alopecia
agent which can desirably be essentially free of antihypertensives,
for example, to stimulate cosmetic hair growth.
In one embodiment, the present invention provides a method for
stimulating hair growth. The method comprises the step of applying
to skin in a topical pharmaceutical carrier a transition metal compound
having SOD activity. The SOD active compound is selected from one
or more of copper salicylate, copper aspirinate, indomethacin-copper
and a complex of an amino acid or peptide and a transition metal.
The amino acid is selected from one or more of glycine, histidine,
lysine, arginine, cysteine and methionine, and the metal is selected
from one or more of copper, iron, zinc and manganese. The peptide
consists of glycine, histidine, lysine, arginine, cysteine or methionine.
The peptide is selected from one or more of histidyl lysine, glycyl
histidine, glycyl hystidyl lysine and lysyl histidyl lysine.
In another embodiment, the present invention provides a composition
suitable for treating hair loss. The composition comprises a transition
metal compound having SOD activity formulated in a suitable topical
pharmaceutical carrier. The SOD active compound is selected from
copper salicylate, copper aspirinate, indomethacin-copper and a
complex of an amino acid and a transition metal. The amino acid
is selected from glycine, histidine, lysine, arginine, cysteine
and methionine, and the metal is selected from copper, iron, zinc
and manganese.
In a further embodiment, the present invention provides a composition
useful for treating hair loss comprising a transition metal compound
of the formula R-M having superoxide dismutase activity. R is a
salicyl, acetylsalicyl or indomethacin group and M is copper, iron,
zinc or manganese. The composition includes a topical pharmaceutical
carrier.
DETAILED DESCRIPTION OF THE INVENTION
In the present invention, superoxide dismutase (SOD) is compounded
in a topical formulation. The pharmaceutical carrier, in which the
SOD is generally substantially homogeneously dispersed can be an
aqueous dispersion or suspension, or a water-in-oil or oil-in-water
emulsion. Pharmaceutical carriers which can be mentioned include
water, urea, alcohols and glycols such as methanol, ethanol, propanol,
butanol, ethylene glycol, propylene glycol, and the like.
Suitable water-in-oil emulsions are commercially available under
the designations Aquaphor, cold cream, Eucerin, hydrous lanolin,
Hydrosorb hydrophilic petrolatum, Nivea, Polysorb, Qualatum and
Velvachol. Suitable oil-in-water emulsions are available commercially
under the designations acid mantle cream, Almay emulsion cream,
Cetaphil, Dermabase, Dermavan, hydrophilic ointment, Keri cream,
Lubriderm cream, Multibase cream, Neobase cream, Unibase cream,
Vanibase cream and Wibi. The carrier may further contain various
other emollients, emulsifiers, water, perfumes, colorants, preservatives,
and the like. The topical formulation is in the form of a cream,
lotion, shampoo, cream rinse, or the like.
The SOD can be enzymatic or an enzyme mimic, such as, for example,
metal complexes of amino acids, peptides and other organic acids.
Complexes of zinc and the transition metals, typically copper, iron
and manganese, are known to have SOD activity. Preferred amino acids
and peptides include the amino acids glycine, histidine, lysine,
arginine, cysteine, methionine, and the like, and peptides comprised
predominantly thereof. Representative examples include copper salicylate,
copper aspirinate and indomethacin-copper.
Effective amounts of the SOD generally range from about 0.01 to
about 20% by weight of the topical composition, more preferably
from about 0.1 to about 10% by weight, most preferably from about
0.5 to about 3% by weight, but more or less can be present in the
composition depending on the particular SOD formulation and the
treatment conditions. In general, topical applications to the scalp
of SOD having about 300 units of activity per application, or more,
are sufficient.
The topical SOD can be used alone or in combination with other
hair growth stimulants or additaments ,which are available to enhance
hair growth stimulation, such as, for example, the hydroxyl radical
scavengers, antiandrogens and others described in International
Publication No. WO 87/00427 (International Application No. PCT/US86/01393)
published on Jan. 29, 1987; and European Patent Application No.
89300785.6, Publication No. 0327263/A1, published Aug. 9, 1989;
both of which are hereby incorporated in their entirety herein as
though fully set forth verbatim, including reference therein to
the publication of Ross & Ross, "Selected Specific Rates
of Reactions of Transients From Water In Aqueous Solution. III.
Hydroxyl Radical and Pure Hydroxyl Radicals and Their Radical Ions,"
National Standard Reference Data Series, National Bureau of Standards,
59 (1977), which is also incorporated herein by reference.
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