Weight loss abstract
The present invention involves a dietary supplement that can be
used as a weight loss composition. The composition comprises of
an essentially dry mixture of chromium, L-carnitine, gamma-linolenic
acid, (-) hydroxycitric acid, choline, inositol, antioxidants and
herbs. The preferred antioxidants are Coenzyme Q10 and the herbs
are ginkgo biloba leaves. The essentially dry mixture can be prepared
as a beverage and delivered enterally. The present invention also
involves a method for inducing weight loss in a mammal. The method
involves administering to a mammal, preferably a human, a weight
loss inducing effective amount of the above described essentially
dry mixture. The weight loss inducing effective amount of the above
composition is administered daily in at least two separate portions
of 7.325 grams each.
Weight loss claims
We claim:
1. A weight loss composition comprising:
250 to 500 mg (-) hydroxycitric acid;
50 to 125 mg L-carnitine;
25 to 100 mcg Chromium;
25 to 100 mg Choline;
25 to 100 mg Inositol;
25 to 100 mg Gamma-Linolenic Acid;
15 to 75 mg herbs; and
5 to 30 mg antioxidants.
2. The composition of claim 1 wherein the herbs are ginkgo biloba
leaves and the antioxidants are Coenzyme Q10.
3. The composition of claims 1 or 2 further comprising 0.15 to
0.35 g soy lecithin, 0 to 10 g carbohydrates, and 0.1 to 0.5 g oat
flour.
4. The composition of claim 3 where the carbohydrates are maltodextrin
and the oat flour is hydrolyzed.
5. A weight loss composition comprising:
250 to 500 mg (-) hydroxycitric acid;
50 to 125 mg L-carnitine;
25 to 100 mcg Chromium;
25 to 100 mg Choline;
25 to 100 mg Inositol;
25 to 100 mg Gamma-Linolenic Acid;
15 to 75 mg Ginkgo Biloba Leaves; and
5 to 30 mg Coenzyme Q10.
6. The composition of claim 5 further comprising 0.15 to 0.35 soy
lecithin, 0 to 10 g carbohydrates, and 0.1 to 0.5 g oat flour.
7. The composition of claim 6 where the carbohydrates are maltodextrin
and the oat flour is hydrolyzed.
8. A weight loss composition comprising:
375 mg (-) hydroxycitric acid;
75 mg L-Carnitine;
50 mcg Chromium;
50 mg Choline;
50mg Inositol;
501 mg Gamma-Linolenic Acid;
b 33 mg Ginkgo Biloba Leaves; and
15 mg Coenzyme Q10.
9. The composition of claim 8 further comprising 0.18 g soy lecithin,
5.3 g carbohydrates, and 0.33 g oat flour.
10. An aqueous beverage composition to facilitate weight loss comprising:
250 to 500 mg (-) hydroxycitric acid;
50 to 125 mg L-carnitine;
25 to 100 mcg Chromium;
25 to 100 mg Choline;
25 to 100 mg Inositol;
25 to 100 mg Gamma-Linolenic Acid;
15 to 75 mg Ginkgo Biloba Leaves; and
5 to 30 mg Coenzyme Q10.
11. The aqueous beverage composition of claim 10 further comprising
0.15 to 0.35 g soy lecithin, 0 to 10 g carbohydrates, and 0.1 to
0.5 g oat flour.
12. The aqueous beverage composition of claim 11 wherein the carbohydrates
are maltodextrin and the oat flour is hydrolyzed.
13. A method of inducing weight loss in a mammal, comprising administering
to said mammal a weight loss inducing effective amount of the composition
of claim 1.
14. The amount of claim 13 wherein the weight loss inducing effective
amount is administered at least daily in two separate portions of
7.325 grams each.
15. A method of inducing weight loss in a mammal, comprising administering
to said mammal a weight loss inducing effective amount of the composition
of claim 5.
16. The method of claim 15 wherein the weight loss inducing effective
amount is administered daily in two separate portions of 7.325 grams
each.
17. A method of inducing weight loss in a mammal, comprising administering
to said mammal a weight loss inducing effective amount of the composition
of claim 8.
18. The method of claim 17 wherein the weight loss inducing effective
amount is administered at least daily in two separate portions of
7.325 grams each.
19. A method of inducing weight loss in a mammal, comprising administering
to said mammal a weight loss inducing effective amount of the composition
of claim 10.
20. The method of claim 19 wherein the weight loss inducing effective
amount is administered daily in at least two separate portions of
7.325 grams each.
Weight loss description
FIELD OF THE INVENTION
This invention relates to a composition that supplies chromium,
L-carnitine, gamma-linolenic acid, (-) hydroxycitric acid, choline,
inositol, antioxidants and herbs to the human body. The composition
of this invention can be used as a dietary supplement to help facilitate
weight loss. The composition can be prepared as a beverage and delivered
enterally.
BACKGROUND AND SUMMARY OF THE INVENTION
At the beginning of each year, millions of Americans make a resolution
that they are going to lose weight. In order to help them lose weight,
many people employ the use of a over-the-counter weight loss product.
For example, the below listed weight loss products are presently
available:
1. Citrimax.RTM. Power (by Natures Herbs)--Provides Citrimax.RTM.
which is a stabilized non-lactonized calcium salt of the free form
of (-) hydroxycitric acid.
2. Energy (by Excel)--Provides 20 mg of (-) HCA, chromium, Uva
Ursi, Cayenne, Ma Huang and Kola Nut.
3. Citrimax.RTM. Plus (by Natrol)--Provides 250 mg of (-) HCA,
Uva Ursi, Chromium, and Cascara Sagrada.
4. Litening (by New Resolution)--Provides 125 mg of (-) HCA, chromium,
yerba mate, ginseng, L-carnitine tartrate, green tea extract, hymnema
sylvestre extract.
5. Smartbody (by Life Extension)--Provides an unlisted amount of
(-) HCA, guarana extract, ma huang, ginger root, white willow, taurine,
ascorbic acid, protease, yucca extract, amylase, bladderwrack, to-ti
extract, ginkgo biloba, hawthorne berry saw palmetto, calcium borate,
cellulase, chromium, lipase.
6. Citralean (by Advanced Research Products)--Provides (-) HCA,
chromium, vanadyl sulfate, hymnema sylvestre.
7. Mega Fat Burner (by Proline)--Provides (-) HCA, chromium, L-carnitine.
The present invention involves a composition which is initially
prepared as an essentially dry mixture that can be used as a dietary
supplement to facilitate weight loss. More specifically, this composition
is prepared by blending together a series of ingredients. These
ingredients are: 250 to 500 mg (-) hydroxycitric acid, 50 to 125
mg L-carnitine, 25 to 100 mg chromium, 25 to 100 mg choline, 25
to 100 mg inositol 25 to 100 mg gamma-linolenic acid, 15 to 75 mg
herbs and 5 to 30 mg antioxidants. The herbs are ginkgo biloba leaves
and the antioxidants are preferably Coenzyme Q10. In addition to
the above identified ingredients, the composition may also contain
0.15 to 0.35 g soy lecithin, 0 to 10 g carbohydrates and 0.1 to
0.5 g hydrolyzed oat flour.
The preferred composition of this invention contains 375 mg (-)
hydroxycitric acid, 75 mg L-carnitine, 50 mcg chromium, 50 mg choline,
50 mg inositol, 50 mg gamma-linolenic acid, 33 mg ginkgo biloba
leaves and 15 mg Coenzyme Q10. Additionally, the composition contains
0.18 g soy lecithin, 5.33 g carbohydrates and 0.33 g hydrolyzed
oat flour.
The present invention also involves a method for inducing weight
loss in a mammal by administering to said mammal a weight loss-inducing
effective amount of the composition described above. The weight
loss inducing effective amount of the composition is preferably
administered at least twice a day in two separate portions of 7.325
grams each.
Once the essentially dry mixture has been blended, the composition
can be delivered enterally as a beverage. The beverage is prepared
by dissolving the proper amount of the essentially dry mixture in
water, juice, milk or any other drinkable liquid. The recommended
serving size is about 7.325 grams of the essentially dry mixture
in 8 ounces of water, juice, or other ingestible liquid. As stated
above, it is preferred that the recommended serving size be consumed
at least twice a day.
The present composition is a dietary supplement containing several
ingredients designed to help burn fat stores as well as reduce the
synthesis of fats. The composition burns fat by: (1) the use of
L-carnitine which transports fat from storage to be burned for energy;
(2) the use of gamma linolenic acids to increase thermogenesis;
(3) the use of lipotropics which serve to prevent the accumulation
of fat in the liver by dissolving and mobilizing the fat stores;
and (4) the use of Coenzyme Q10 which improves the efficiency of
energy production at the cellular level. Furthermore, the present
composition reduces synthesis of fats by: (1) the use of (-) hydroxycitric
acid which inhibits the actions of ATP-citrate lyase; and (2) reducing
the availability of acetyl-CoA, the building block for fatty acid
and cholesterol synthesis.
DETAILED DESCRIPTION OF THE INVENTION
The present invention involves a composition for human consumption
that contains chromium, L-carnitine, gamma-linolenic acid, (-) hydroxycitric
acid, choline, inositol, antioxidants and herbs. This composition
can be used as a dietary supplement to facilitate weight loss. More
specifically, this composition is a weight-loss product that actively
blocks and burns fat while curbing appetite and reducing cravings.
In addition, this composition increases the rate and efficiency
that the body burns fat by increasing thermogenesis (the burning
and release of excess calories as heat) and provides components
essential to fat burning.
The composition of this invention is initially prepared as an essentially
dry mixture. This mixture is prepared by blending together the proper
amounts of all the required ingredients. Once blended, the composition
can be delivered enterally as a beverage. The beverage is prepared
by dissolving the proper amount of the essentially dry mixture in
water, juice, or any other drinkable liquid such as Reliv Ultrim.RTM.
meal replacement product or Reliv Fibrestore.RTM. fiber and antioxidant
supplement, by Reliv International, of Chesterfield, Mo., the assignee
of the present application.
The composition of this invention can also be formulated into a
lozenge by mixing the ingredients thereof into a flavored hard candy
sugar base, and then subjecting this mixture to a conventional fusion
or candy molding process. Additional formulations of the composition
include capsules, tablets, emulsions and suspensions. Furthermore,
the weight loss composition can be included in staple foods such
a cakes, cookies, weight loss candy bars, etc.
In order to effectuate weight loss in a mammal such as a human,
a weight loss-inducing effective amount of the essentially dry composition
should be administered to said mammal. The weight loss-inducing
effective amount and recommended per serving size of the composition
is 7,325 grams of the essentially dry mixture. The weight loss inducing
effective amount of the essentially dry mixture should be consumed
at least twice a day, preferably in 8 ounces of water, juice, milk
or other ingestible liquid. As used herein, the term, "per
serving" means 7,325 grams of the essentially dry mixture mixed
with 8 ounces of an ingestible liquid.
Ingredients
The composition of the present invention includes the electrolyte
chromium. Chromium is present in the formulation from about 25 to
100 mcg but preferably 50 mcg. Chromium is delivered via niacin
bound chromium polynicotinate. The preferred delivery vehicle is
ChromeMate.RTM., by Interhealth Company, Concord, California. ChromeMate.RTM.
is described in U.S. Pat. Nos., 4,923,855, 4,954,49 and 5,194,615,
herewith incorporated by reference. However, other suitable niacin
bound chromium polynicotinate delivery vehicles can be used.
Niacin bound chromium polynicotinate has been shown to lower blood
lipid levels. Additionally, certain biologically active chromium
complexes have been identified as a cofactor for insulin, such as
GTF. These chromium complexes are responsible for binding insulin
to cell membrane receptor sites. At these sites, insulin transports
blood sugar (glucose) and vital amino acids inside the cell for
energy and protein synthesis. See Rosenbaum, "Choosing A Chromium
Supplement" the Interhealth Chromium Series:1 (1990).
Chromium is an important nutrient for controlling blood sugar.
It helps overcome sugar cravings, a problem experienced by many
overweight people due to diets high in sugars and refined carbohydrates.
Chromium also helps level out the highs and lows of a high carbohydrate
diet, promoting a steady stream of available glucose for continuous,
prolonged energy.
Chromium also plays an important role controlling blood lipids,
lowering harmful LDL cholesterol and increasing beneficial HDL cholesterol.
Chromium also plays a part in the growth of muscle and the control
of body fat.
The composition also contains the non-protein amino acid L-carnitine.
L-carnitine present in the composition is from about 50 to 125 mg,
but preferably is 75 mg. The L-Carnitine may be delivered in the
form of L-Carnitine L-Tartrate, however, any other form of L-carnitine
can be used.
The primary role of L-carnitine in the body is as a biocatalyst.
Fats are burned for energy inside muscle cells in the cell organelle
known as the mitochondria. Fats are stored in adipose cells and
cannot pass through the mitochondria unless they are transported
by L-carnitine. Thereupon, the amount of fat burned in the body
depends on the level of L-carnitine in the muscle. The higher the
level of L-carnitine in the body, the greater the amount of body
fat used for fuel.
For those who do find it appropriate to diet, L-carnitine accelerates
the loss of body fat without sacrificing excessive loss of lean
mass. (-) Hydroxycitric Acid (HCA) has a similar effect. Studies
of athletes supplementing their diet with L-carnitine showed a significant
increase in the use of fat during exercise.
L-carnitine also reduces fatigue, is used in the treatment of atherosclerotic
heart diseases, advantageously increases HDL cholesterol while lowering
LDL cholesterol, and decreases ketone levels in the blood.
The composition also contains gamma-linoleic acid (also known as
Omega). The amount of gamma-linoleic acid in the composition is
from about 25 to 100 mg, but preferably 50 mg. Gamma-linoleic acid
is a polyunsaturated fatty acid which occurs as a glyceride in many
seed fats. It is an essential fatty acid in the diet. The gamma-linoleic
acid may be delivered in the form of Borage Oil Powder available
from Traco Labs (Seymour, Illinois); however, other forms can be
used.
Gamma-linoleic acid is used to facilitate weight loss by causing
thermogenesis. In addition, gamma-linoleic acid appears to increase
the level of brown fat Na/K ATPase activity. Brown fat readily burns
fat stores for energy and the specific enzyme Na/K ATPase controls
the rate of metabolism.
Furthermore, gamma-linoleic acid is known to have some important
anti-inflammatory properties, is used to combat high blood pressure,
lowers blood viscosity and reduces LDL cholesterol, and is known
to improve immune response.
The composition also contains (-) hydroxycitric acid (referred
to herein as "HCA"). The amount of (-) HCA present is
from about 250 to 500 mg, but preferably 375 mg. The preferred delivery
vehicle for (-) HCA is Citrimax.RTM., available from Interhealth
Company, Concord, California. Citrimax.RTM. is a stabilized non-lactonized
calcium salt of the free form of (-) HCA. However, other delivery
vehicles can be used.
(-) HCA reduces the conversion of carbohydrate calories into fats.
It does this by inhibiting the actions of ATP-citrate lyase, the
enzyme which converts citrate into fatty acids and cholesterol in
the primary pathway of fat synthesis in the body. The actions of
(-) HCA increase the production and storage of glycogen (which is
found in the liver, small intestine and muscles of mammals) while
reducing both appetite and weight gain. (-) Hydroxycitric acid also
causes calories to be burned in an energy cycle similar to thermogenesis.
(-) HCA also increases the clearance of LDL cholesterol, reduces
appetite, does not cross the blood-brain barrier, does not stimulate
the central nervous system, does not cause insomnia, nervousness,
depression, hypertension or rapid heart rate associated with most
prescription and over the counter diet aids and can be combined
with other nutrients to enhance benefits.
The composition also contains from about 25 to 100 mg choline and
from about 25 to 100 mg inositol. It is preferred that the composition
contain 50 mg of choline and 50 mg of inositol. The choline can
be delivered in the form of choline bitartrate, but other forms
can be used. The inositol can be delivered in any form suitable
for use.
Choline and inositol are members of the vitamin B complex which
are classified as lipotropics. Lipotropics serve to prevent the
accumulation of fat in the liver by dissolving and mobilizing the
fat stores. Lipotropics also detoxify the waste by-products of protein
synthesis, increase resistance to disease by stimulating the activity
of the thymus gland, increase the production of lecithin in the
liver and reduce LDL cholesterol and increase HDL cholesterol.
The composition also contains antioxidants. The preferred antioxidant
is coenzyme Q10 (coQ10). The amount of coenzyme Q10 present in the
composition is from about 5 to 30 mg, but preferably 15 mg.
Coenzyme Q10 is also called a ubiquinone because it is present
in nearly all cells of the body, is obtained from the diet, and
is also produced by the body. Like L-carnitine, CoQ10 plays an important
role with mitochondria. Coenzyme Q10 helps produce adenosine triphosphate
(ATP), which is a chemical responsible for the storage of energy
in the body. Therefore, CoQ10 is essential for virtually all energy
production.
In weight loss, CoQ10 improves the efficiency of energy production
at the cellular level. Coenzyme Q10 is also used to maintain immunity
function and lowering blood pressure.
The composition also contains herbs. The preferred herb is ginkgo
biloba leaves. The amount of ginkgo biloba leaves present in the
invention is from about 15 to 75 mg, but preferably 33 mg. Ginkgo
biloba leaves is known to have some antioxidant activity. More particularly,
its antioxidant activity extends to the central nervous system and
the eye with protective effects noted for the retina. Ginkgo biloba
leaves also as act an anti depressant.
Other Ingredients
In addition to the above disclosed ingredients, the invention can
also contain lecithin, flavoring agents, hydrolyzed oat flour and
carbohydrates.
The composition of this invention may include a lecithin, preferably
soy lecithin. The amount of soy lecithin that can be used is in
the range of 0.15 to 0.35 g, but preferably in the amount of 0.18
g per serving. The soy lecithin is used as an emulsifier and processing
aid to improve flow properties.
The composition can also include hydrolyzed oat flour. The amount
of hydrolyzed oat flour present in the composition is in the amount
0.1 to 0.5 g, but preferably 0.33 g. The hydrolyzed oat flour can
be Quaker Oatrim.RTM.(Quaker Oat Company, Chicago, Ill.), such as
Oatrim.RTM. 5Q. Studies have found that individuals taking Quaker
Oatrim.RTM. exhibited a substantial drop in artery-clogging LDL
cholesterol without a decrease in beneficial HDL cholesterol. Additionally,
their ability to process sugar from a meal improved significantly.
These studies have also shown that Oatrim.RTM. is a factor in weight
loss. In one study, twenty-four volunteers exhibited weight loss
while taking Oatrim.RTM. despite increases in their caloric intake.
The composition can be used unflavored or can contain flavoring
agents or additives. The flavoring additives can include fruit flavors,
botanical flavors and mixtures thereof. As used herein, the term
"fruit flavor" denotes flavors derived from natural edible
reproductive prepared flavors made to stimulate fruit flavors derived
from natural sources. Flavoring additives can include pineapple
flavor, orange flavor, lemon flavor, lime flavor, fruit punch and
mixtures thereof. Other flavors such as grape flavor, cherry flavor,
apply flavor and mixtures thereof can also be used. The amount of
the flavor to be used depends upon the flavor or flavors selected,
the flavor impression desired, and the form of flavor added.
The composition may also include a carbohydrate source. In particular,
the composition can contain the carbohydrate maltodextrin. Maltodextrin
is a complex carbohydrate. The amount of maltodextrin present in
the composition is in the amount of 0 to 10, but preferably, 5.33
g. Maltodextrin is used as a blending base.
EXAMPLE 1
Table 1 shows how to make a weight-loss composition within the
scope of the invention. The composition is prepared by mixing the
ingredients listed below to form an essentially dry mixture. To
make an orally deliverable beverage composition within the scope
of this invention, 7.325 grams of this blended essentially dry mixture
is mixed with 8 ounces of water, juice, milk or other liquid. To
effectuate weight loss, the resulting weight loss beverage is consumed
at least twice a day.
TABLE 1 ______________________________________ Ingredient Pounds
% ______________________________________ Citrimax.RTM. 82.48 10.31
Maltodextrin QD 500 582.75 72.84 OATRIM 5Q 36.16 4.52 L-Carnitine-L-Tartrate
13.36 1.67 Borage Oil Powder 39.76 4.97 (15% GLA) Ginkgo Biloba
Leaves 3.60 0.45 Lecithin 20.00 2.50 Choline Bitartrate 13.68 1.71
Inositol 6.48 0.81 Coenzyme Q10 1.68 0.21 Chromate.RTM. 0.054 0.0067
Totals 800.00 100.00 ______________________________________
EXAMPLE 2
This example demonstrates the blending procedure that can be used
to make the weight loss composition of the present invention.
Blending Procedure
1. Check Staged Pallets and Barrels for Correct:
A. Quality Assurance Release
B. Batch Numbers
C. Paperwork
2. Arrange partial and full bag ingredients on a pallet for rapid
addition to blender.
3. Turn on blender for continuous mix.
4. Add maltodextrin QD M500.
5. Gradually add liquid lecithin. Blend for eight (8) minutes.
6. Add in order while blending following ingredients:
A. Oatrim 5Q
B. Citrimax.RTM.
C. Borage Oil Powder
D. Choline Bitartrate
E. Inositol
F. Coenzyme Q 10
G. L-Carnitine L-Tartrate
H. ChromeMate.RTM.*
I. Ginkgo Biloba Leaves* * Mix With partial of Citrimax.RTM.
7. Blend eight (8) minutes.
8. Upon blending completion, test and sample.
Although the invention has been described primarily in connection
with special and preferred embodiments, it will be understood that
it is capable of modification without departing from the scope of
the invention. The following claims are intended to cover all variations,
uses, or adaptations of the invention, following, in general, the
principles thereof and including such departures from the present
disclosure as come within known or customary practice in the field
to which the invention pertains, or as are obvious to persons skilled
in the field. |